Earnings before Interest, Tax, Depreciation and Amortization (EBITDA)
Based on: 10-K (reporting date: 2025-12-28), 10-K (reporting date: 2024-12-29), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).
The financial performance, as indicated by earnings metrics, exhibits fluctuations over the five-year period. A notable trend is the increase in EBITDA from 2021 to 2025, despite interim declines. Net earnings demonstrate significant volatility, while both EBIT and EBT show a similar pattern of decline followed by recovery.
- EBITDA Trend
- EBITDA began at US$30,349 million in 2021, decreased to US$23,320 million in 2023, and then increased substantially to US$41,055 million in 2025. The 2022 value of US$28,971 million represents a moderate decrease from the prior year, while 2024 shows a slight increase to US$24,781 million before the significant jump in 2025. This suggests improving operational profitability in the latter years of the period.
- Relationship between EBITDA and Other Earnings Metrics
- EBITDA consistently exceeds EBIT and EBT throughout the period, as expected, due to the exclusion of depreciation, amortization, interest, and taxes. The difference between EBITDA and EBIT is relatively stable, indicating consistent depreciation and amortization expenses. However, the gap between EBIT and EBT fluctuates, reflecting changes in the tax burden.
- Net Earnings Volatility
- Net earnings experienced a decrease from US$20,878 million in 2021 to US$17,941 million in 2022, followed by a substantial increase to US$35,153 million in 2023. A significant decline occurred in 2024, with net earnings falling to US$14,066 million, before recovering to US$26,804 million in 2025. This volatility suggests that factors beyond operational profitability, such as tax rates or one-time events, significantly impact the bottom line.
- EBIT and EBT Movements
- Both EBIT and EBT followed a similar trajectory. They decreased from 2021 to 2023, reaching lows of US$15,834 million and US$15,062 million respectively, then increased in 2024 and 2025 to US$33,552 million and US$32,581 million. This parallel movement indicates a strong correlation between operational performance and tax implications.
In summary, the period demonstrates a complex financial picture. While EBITDA shows a positive long-term trend, net earnings are subject to considerable fluctuation. The recovery in EBITDA, EBIT, and EBT in 2024 and 2025 suggests a potential improvement in underlying business performance, but the volatility of net earnings warrants further investigation.
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Enterprise Value to EBITDA Ratio, Current
| Selected Financial Data (US$ in millions) | |
| Enterprise value (EV) | 609,870) |
| Earnings before interest, tax, depreciation and amortization (EBITDA) | 41,055) |
| Valuation Ratio | |
| EV/EBITDA | 14.85 |
| Benchmarks | |
| EV/EBITDA, Competitors1 | |
| AbbVie Inc. | 25.57 |
| Amgen Inc. | 14.37 |
| Bristol-Myers Squibb Co. | 10.16 |
| Danaher Corp. | 21.06 |
| Eli Lilly & Co. | 33.70 |
| Gilead Sciences Inc. | 14.52 |
| Merck & Co. Inc. | 11.35 |
| Pfizer Inc. | 12.07 |
| Regeneron Pharmaceuticals Inc. | 12.54 |
| Thermo Fisher Scientific Inc. | 17.60 |
| Vertex Pharmaceuticals Inc. | 23.17 |
| EV/EBITDA, Sector | |
| Pharmaceuticals, Biotechnology & Life Sciences | 17.75 |
| EV/EBITDA, Industry | |
| Health Care | 17.11 |
Based on: 10-K (reporting date: 2025-12-28).
1 Click competitor name to see calculations.
If the company EV/EBITDA is lower then the EV/EBITDA of benchmark then company is relatively undervalued.
Otherwise, if the company EV/EBITDA is higher then the EV/EBITDA of benchmark then company is relatively overvalued.
Enterprise Value to EBITDA Ratio, Historical
| Dec 28, 2025 | Dec 29, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | ||
|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||
| Enterprise value (EV)1 | 608,279) | 390,710) | 383,498) | 428,242) | 439,101) | |
| Earnings before interest, tax, depreciation and amortization (EBITDA)2 | 41,055) | 24,781) | 23,320) | 28,971) | 30,349) | |
| Valuation Ratio | ||||||
| EV/EBITDA3 | 14.82 | 15.77 | 16.45 | 14.78 | 14.47 | |
| Benchmarks | ||||||
| EV/EBITDA, Competitors4 | ||||||
| AbbVie Inc. | 26.08 | 26.97 | 20.79 | 13.31 | 13.44 | |
| Amgen Inc. | 14.47 | 15.31 | 14.13 | 12.97 | 13.22 | |
| Bristol-Myers Squibb Co. | 10.28 | 48.23 | 6.51 | 9.46 | 8.65 | |
| Danaher Corp. | 23.29 | 22.34 | 26.41 | 18.42 | 21.05 | |
| Eli Lilly & Co. | 35.45 | 55.99 | 85.35 | 37.76 | 29.86 | |
| Gilead Sciences Inc. | 14.76 | 35.86 | 10.41 | 13.89 | 8.57 | |
| Merck & Co. Inc. | 12.07 | 9.90 | 51.30 | 13.91 | 12.18 | |
| Pfizer Inc. | 12.25 | 10.60 | 22.50 | 6.12 | 8.64 | |
| Regeneron Pharmaceuticals Inc. | 13.07 | 13.55 | 20.16 | 15.27 | 6.68 | |
| Thermo Fisher Scientific Inc. | 19.40 | 19.89 | 21.83 | 20.25 | 20.21 | |
| Vertex Pharmaceuticals Inc. | 24.32 | 231.93 | 21.57 | 14.91 | 18.92 | |
| EV/EBITDA, Sector | ||||||
| Pharmaceuticals, Biotechnology & Life Sciences | 18.39 | 22.07 | 22.59 | 13.58 | 13.16 | |
| EV/EBITDA, Industry | ||||||
| Health Care | 17.72 | 21.03 | 20.27 | 14.00 | 14.33 | |
Based on: 10-K (reporting date: 2025-12-28), 10-K (reporting date: 2024-12-29), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).
3 2025 Calculation
EV/EBITDA = EV ÷ EBITDA
= 608,279 ÷ 41,055 = 14.82
4 Click competitor name to see calculations.
The Enterprise Value to EBITDA ratio exhibited fluctuations over the five-year period. Initially, the ratio increased before decreasing again, suggesting shifts in the market’s assessment of the company’s value relative to its operating performance.
- Enterprise Value (EV)
- Enterprise Value decreased from US$439,101 million in 2021 to US$383,498 million in 2023, representing a decline over two years. A slight increase to US$390,710 million was observed in 2024, followed by a substantial rise to US$608,279 million in 2025.
- Earnings Before Interest, Tax, Depreciation, and Amortization (EBITDA)
- EBITDA experienced a decline from US$30,349 million in 2021 to US$23,320 million in 2023. Similar to Enterprise Value, EBITDA showed an increase in 2024, reaching US$24,781 million, and a significant increase in 2025, reaching US$41,055 million.
- EV/EBITDA Ratio – Trend Analysis
- The EV/EBITDA ratio began at 14.47 in 2021 and increased to 14.78 in 2022. A subsequent increase to 16.45 was noted in 2023, indicating a relatively higher valuation multiple. The ratio then decreased to 15.77 in 2024. Finally, the ratio decreased to 14.82 in 2025, despite the substantial increases in both EV and EBITDA, suggesting that the growth in EBITDA outpaced the growth in Enterprise Value during that year.
The concurrent movements in Enterprise Value and EBITDA suggest a correlation between overall company valuation and operating profitability. The increase in both metrics in 2025, coupled with the decreasing ratio, indicates a potentially more favorable valuation from an EBITDA perspective at the end of the observed period.
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